TRIP13 Functions in the Establishment of the Spindle Assembly Checkpoint by Replenishing O-MAD2
Summary: Hose End The spindle assembly checkpoint (SAC) prevents premature segregation of chromosomes during mitosis.This process requires structural remodeling of MAD2 from O-MAD2 to C-MAD2 conformation.After the checkpoint is satisfied, C-MAD2 is reverted to O-MAD2 to allow anaphase-promoting complex/cyclosome (APC/C) to trigger anaphase.Recently